Results
i) The Dm-dNK gene is expressed in gene level (60% positives).
ii) Dm-dNK protein (≈ 28 kDa) expression could be detected only in the skeletal muscle.
iii) Thymidine phosphorylation higher in Dm-dNK+/- mice than in wild-type mice.
a. Dm-dNK is highly expressed in kidney, skeletal muscle and brain of Dm-dNK+/-
mice.
b. Dm-dNK enzyme loses activity after 3 months in brain, and after 5 months in
other tissues.
iv) There was no change in the mitochondrial DNA levels, mortality, growth rate and organ
weights of the Dm-dNK transgenic mice.
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Last updated:
05/22/11