Tg6799 mice (2-3 months and 8-10 months of age) were trained to discriminate between monomolecular odorants using an automated liquid dilution olfactometer. Olfactory impairment compared to control mice was detected at 2-3 months of age. Using a simple spatial learning test, also spatial learning impairment was detected at 2-3 months of age.

The figure to the left shows performance of control mice (triangles), 2-3 month old (squares) and 8-10 month old Tg6799 mice (diamonds) in discriminating a monomolecular odorant pair at 0.01 ppm. Each data point represents 20 decisions.