Department of Physics, Chemistry and Biology (IFM)

Conclusion

The tested anti viral compounds showed more significant anti viral activity but also exhibited cytotoxicity . The study could be continued to find an anti-viral compound with non toxic and high virucidal effect.

The future perspective of this HSV-1 antiviral study is also to release these compounds by micro encapsulation into biosynthetic corneas to see the effect. The mechanism of action of these compounds could be studied and it would be interesting to selectively target trigeminal nerve by coupling the drug to a molecule suitable for cellular transport. Patients with chronic HSV keratitis and recurrent graft rejection due to this infection could then have another treatment option for their disease.