Department of Physics, Chemistry and Biology (IFM)

The microarray revealed 1856 upregulated probes in the tinamou heart. Out of these, a number of genes were identified to be involved in various proliferative processes such as cardiac remodeling and angiogenesis, processes associated with increased cardiac workload and cardiac hypoxia.

Three genes were found to be upregulated which is major key players in glycolysis.

Phosphofructokinase-1 (PFK-1) is a bottle neck enzýmes that catalyzes the first irreversible step in glycolysis by the conversion of Fructose-6-phosphate to fructose-1,6.bisphosphate.

Phosphofructokinase-2/Fructose-2,6-bisphophatase 2 is a main regulator of PFK-1by catalyzing the conversion of Fructose-6-phosphate into Fructose-2,6-phosphate which activates PFK-1.

Adolase B is an ezymes that catalyzes the subsequent step from fructose-1,6-bisphophate into glyceraldhyde-3-phosphate which is furtherprocessed to pyruvate.

The microarray analysis also identified genes involved in cardiac hypertrophy, further reinforcing previous morphological findings in the tinamou heart.